Reservatrol is a polyphenol that works as an antioxidant. It is known to be in red wine. But a glass of red wine is not enough to get meaningful reservatrol benefits. Read more about daily reservatrol needs and how you can get the full beauty and health benefits of Reservatrol.
What Foods Contain Reservatrol
Reservatrol is found in red wine but to a lesser degree compared to some foods. Reservatrol is found in:
- dark chocolate
Reservatrol is also available in supplement form.
Health Benefits of Reservatrol
As an anti-oxidant, it provides certain benefits. But the main benefit of Reservatrol is that it boosts sirtuins. Our body has sirtuins, but they slow down with age.
Sirtuins are important because they tell our cells to repair themselves. In this way, reservatrol extends the life of cells.
A boost in sirtuins can be very helpful for cardiovascular and metabolic diseases. 
Reservatrol also can extend longevity in a manner that is similar to the benefits of caloric restriction.[3,4]
One study found life-prolonging benefits of Reservatrol supplementation included:
- increased insulin sensitivity
- lower blood sugar
- better mitochondrial energy production
- improved motor function. 
Other studies show:
- The potent antioxidant activity may be responsible for its neuroprotective effects. [6,7]
- Reservatrol combined with calcium was found more effective than calcium alone in building bone mass. 
- In lab studies, Grape seed extract effectively inhibited the growth of human colorectal tumor cells. 
But just boosting sirtuins with the Reservatrol from red wine won’t keep them functioning. More is needed for maximum benefit. 
The Beauty Benefits
Topical Reservatrol is used in skincare products. It reverses aged cells to a younger, more active state. It has poor bioavailability  so it is most beneficial when paired with other topical actives.
Why Reservatrol Supplementation Is Necessary
Studies find that a glass of red wine contains 90mcg, or about 1/220th the Reservatrol necessary for basic cell restoration. 
Reservatrol Daily Dosage
Research studies show optimal Reservatrol supplement dosage varies by type of health issue.
An issue is absorption is generally poor. Some experience stomach upset with higher levels of supplementation.
For general cell maintenance, benefits are found at 20mg of Reservatrol a day (20,000 mcg). Some studies range up to 100mg daily taken for a 2-3 months interval for an extra boost.
Summary of Daily Reservatrol Needs
A glass of red wine is not enough reservatrol to maintain a healthy body. Supplementation is generally necessary along with reservatrol rich foods
- Grabowska, Wioleta et al. “Sirtuins, a promising target in slowing down the ageing process. “ Biogerontology vol. 18,4 (2017): 447-476. doi:10.1007/s10522-017-9685-9
- Kane AE, Sinclair DA. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018 Sep 14;123(7):868-885. doi: 10.1161/CIRCRESAHA.118.312498. PMID: 30355082; PMCID: PMC6206880.
- Sinclair DA. Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev. 2005 Sep;126(9):987-1002.
- Valenzano DR, Terzibasi E, Genade T, et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 2006 Feb 7;16(3):296-300
- Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42.
- Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005 Apr 29;280(17):17187-95.
- Guarente L, Picard F. Calorie restriction—the SIR2 connection. Cell. 2005 Feb 25;120(4):473-82.
- Porcu M, Chiarugi A. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends Pharmacol Sci. 2005 Feb;26(2):94-103.
- Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron Artery Dis. 1997 Oct;8(10):645-9.
- McReynolds MR, Chellappa K, Baur JA. Age-related NAD+ decline. Exp Gerontol. 2020 Feb 22;134:110888. doi: 10.1016/j.exger.2020.110888. Epub ahead of print. PMID: 32097708; PMCID: PMC7442590.
- Salehi, Bahare et al. “Resveratrol: A Double-Edged Sword in Health Benefits.“ Biomedicines vol. 6,3 91. 9 Sep. 2018, doi:10.3390/biomedicines6030091
- Folts JD. Potential health benefits from the flavonoids in grape products on vascular disease. Adv Exp Med Biol. 2002;505:95-111.